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APO E EPSILON 4
Descriptors Found:
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DeCS
Descriptor
English
:
Apolipoprotein E4
Descriptor
Spanish
:
Apolipoproteína E4
Descriptor
Portuguese
:
Apolipoproteína E4
Synonyms
English
:
Apo E epsilon 4
Apo E-4
Apo E4
ApoE4
Apolipoprotein E-4
Apo E 4
Apolipoprotein E 4
Tree Number:
D10.532.091.500.750
D12.776.070.400.500.750
D12.776.521.120.500.750
Definition
English
:
A major and the second most common isoform of
apolipoprotein
E. In
humans
, Apo E4 differs from
APOLIPOPROTEIN E3
at only one residue 112 (
cysteine
is replaced by
arginine
), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for
ALZHEIMER DISEASE
and
CARDIOVASCULAR DISEASES.
History Note
English
:
2007 (1982)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
52268
Unique Identifier:
D053327
Occurrence in VHL
:
Similar:
DeCS
CID-10
LILACS